Chondrosarcoma is not characterized by detectable telomerase activity
نویسندگان
چکیده
منابع مشابه
Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo.
TEP1 is a mammalian telomerase-associated protein with similarity to the Tetrahymena telomerase protein p80. Like p80, TEP1 is associated with telomerase activity and the telomerase reverse transcriptase, and it specifically interacts with the telomerase RNA. To determine the role of mTep1 in telomerase function in vivo, we generated mouse embryonic stem (ES) cells and mice lacking mTep1. The m...
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MKT-077, a cationic rhodacyanine dye analogue, causes selective toxicity to cancer cells. Its cellular targets elucidated thus far include oncogenic Ras, F-actin, mortalin (hmot-2)/mthsp70, and telomerase. Here we report that MKT-077 causes growth arrest of cancer cells in culture independent of their Ras, p53, or telomerase status. Telomerase activity is inhibited in vitro by MKT-077 in the te...
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ژورنال
عنوان ژورنال: The Journal of Pathology
سال: 2001
ISSN: 0022-3417,1096-9896
DOI: 10.1002/1096-9896(0000)9999:9999<::aid-path802>3.0.co;2-z